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Synthesis 2014; 46(20): 2771-2779
DOI: 10.1055/s-0034-1378345
DOI: 10.1055/s-0034-1378345
paper
Improved Syntheses of Benzyl Hydraphile Synthetic Cation-Conducting Channels
Further Information
Publication History
Received: 08 April 2014
Accepted after revision: 29 May 2014
Publication Date:
30 July 2014 (online)
Abstract
The tris(macrocycle)s that function in bilayer membranes as ion channels have recently shown versatile new applications such as antibiotic synergists and as agents for direct injection chemotherapy. This report records the development of new and versatile approaches to these molecules that produce significantly better overall yields for a group of previously reported hydraphiles having spacer chains ranging from octylene to hexadecylene.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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