Thioacetamide as an Ammonium Source for Multicomponent Synthesis of 
Pyridines from Aldehydes and Electron-Deficient Enamines or Alkynes

Jie-Ping Wan; Youyi Zhou; Kezhi Jiang; Hongyan Ye

doi:10.1055/s-0034-1378635

Synthesis, Table of Contents

Synthesis 2014; 46(23): 3256-3262
DOI: 10.1055/s-0034-1378635

paper

Thioacetamide as an Ammonium Source for Multicomponent Synthesis of Pyridines from Aldehydes and Electron-Deficient Enamines or Alkynes

Jie-Ping Wan*

^aKey Laboratory of Functional Small Organic Molecule, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. of China

,

Youyi Zhou

^aKey Laboratory of Functional Small Organic Molecule, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. of China

,

Kezhi Jiang

^bKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310012, P. R. of China Fax: +86(791)88120380 Email: wanjieping@jxnu.edu.cn

,

Hongyan Ye

^aKey Laboratory of Functional Small Organic Molecule, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. of China

› Author Affiliations

Abstract

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Abstract

A generally applicable multicomponent method has been established for the synthesis of pyridines. In the reactions, thioacetamide is used as a cheap and efficient ammonium source in a multicomponent reaction with aldehydes and electron-deficient enamines or alkynes to give 3,4,5-trisubstituted pyridines in moderate to good yields and with a high product diversity.

Key words

multicomponent reactions - ring closure - pyridines - aldehydes - enamines - alkynes

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References

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