Thioacetamide as an Ammonium Source for Multicomponent Synthesis of Pyridines from Aldehydes and Electron-Deficient Enamines or Alkynes

Abstract

A generally applicable multicomponent method has been established for the synthesis of pyridines. In the reactions, thioacetamide is used as a cheap and efficient ammonium source in a multicomponent reaction with aldehydes and electron-deficient enamines or alkynes to give 3,4,5-trisubstituted pyridines in moderate to good yields and with a high product diversity.

Key words

multicomponent reactions - ring closure - pyridines - aldehydes - enamines - alkynes

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