Synthesis 2015; 47(23): 3717-3726
DOI: 10.1055/s-0034-1378876
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Chlorin–(Arylamino)quinazoline Hybrids as Models for Multifunctional Drug Development

Alexander V. Nyuchev
a   Department of Chemistry, N.I. Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Avenue, 603950 Nizhny Novgorod, Russian Federation   Email: afnn@rambler.ru
,
Vasiliy F. Otvagin
a   Department of Chemistry, N.I. Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Avenue, 603950 Nizhny Novgorod, Russian Federation   Email: afnn@rambler.ru
,
Andrei E. Gavryushin
b   Nanoscape AG, Am Klopferspitz 19, 82152 Planegg, Germany
,
Yuliya I. Romanenko
c   Research Institute of Macroheterocycles, Ivanovo State University of Chemical Technology, 153000 Ivanovo, Russian Federation
,
Oscar I. Koifman
c   Research Institute of Macroheterocycles, Ivanovo State University of Chemical Technology, 153000 Ivanovo, Russian Federation
,
Dmitrii V. Belykh
d   Institute of Chemistry, Komi Scientific Center, Urals Branch of the Russian Academy of Sciences, 167982 Syktyvkar, Russian Federation
,
Hans-Günther Schmalz
e   Department of Chemistry, University of Cologne, Greinstrasse 4, 50939 Cologne, Germany
,
Alexey Yu. Fedorov*
a   Department of Chemistry, N.I. Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Avenue, 603950 Nizhny Novgorod, Russian Federation   Email: afnn@rambler.ru
› Author Affiliations
Further Information

Publication History

Received: 14 May 2015

Accepted after revision: 07 July 2015

Publication Date:
20 August 2015 (online)


Abstract

A series of multifunctional conjugates each consisting of a fluorescent chlorin photosensitizer and an (arylamino)quinazoline-based epidermal growth factor receptor/vascular endothelial growth factor receptor ligand, potentially useful in site-selective photodynamic antitumor therapy, were prepared and their photochemical properties were investigated.

Supporting Information

 
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