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Synthesis 2015; 47(04): 526-532
DOI: 10.1055/s-0034-1379583
DOI: 10.1055/s-0034-1379583
paper
Copper-Catalyzed Synthesis of Weinreb Amides by Oxidative Amidation of Alcohols
Authors
Further Information
Publication History
Received: 20 August 2014
Accepted after revision: 31 October 2014
Publication Date:
20 November 2014 (online)
Abstract
A simple and efficient protocol has been developed for the oxidative amidation of alcohols to Weinreb amides using tert-butyl hydroperoxide as an oxidant and an inexpensive and air stable copper catalyst. The present protocol is advantageous as it uses commercially affordable alcohols as starting materials. The developed protocol also tolerates various substituted alcohols as starting materials to provide good to excellent yields of the desired products.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1379583.
- Supporting Information (PDF)
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