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DOI: 10.1055/s-0034-1394646
Antinociceptive and anti-inflammatory activities of Elsholtzia ciliata (Thunb.) Hyl. (Lamiaceae) extracts
Introduction: Elsholtzia ciliata (Thunb.) Hyl. (Lamiaceae), is an important Traditional Chinese Medicine (TCM). It has been used to treat a range of diseases such as colds, fevers and oedema for thousands of years [1].
Aim of the study: To evaluate antinociceptive and anti-inflammatory activities of the extracts.
Materials and method: The plant was identified and deposited in the herbarium of the China Pharmaceutical University under the number CPU-2013101802. A crude ethanol (CE) extract and its fractions in hexane (HEX), dichloromethane (DCM) and n-butanol (NBU) were prepared. Extract and fractions were submitted to the formalin test. Acetyl salicylic acid (ASA) was used as positive control.
Results:
Group |
Dose (mg/kg) |
Early phase (seconds) |
Late phase (seconds) |
P value |
Control |
- |
59.23 ± 7.46 |
316.00 ± 50.00 |
- |
ASA |
100 |
42.04 ± 5.29 |
238.59 ± 46.15 |
- |
CE |
100 |
56.50 ± 13.11 |
199.00 ± 55.79* |
0.0034 |
HEX |
100 |
36.35 ± 14.86* |
355.40 ± 130.00 |
0.0050 |
DCM |
100 |
53.74 ± 13.88 |
198.00 ± 27.72* |
0.0011 |
NBU |
10 |
37.98 ± 4.66** |
397.00 ± 93.70 |
0.0002 |
NBU |
30 |
34.68 ± 9.89** |
259.20 ± 46.76 |
0.0006 |
The results were presented as mean ± S.D. (n = 5) of licking time. *p < 0.01 significantly difference compared with the control group. **p < 0.001 significantly difference compared with the control group.
Conclusion: This study strongly proved this plant's antinociceptive and anti-inflammatory potential being this is an important finding as this plant is widely used as an anti-inflammatory TCM in China.
Keywords: Traditional Chinese Medicine, Ethnomedicine, Anti-inflammatory, Antinociceptive, Pharmacology, Formalin
References:
1. A. L. Liu et al. (2007) J.Chin.Pharm.Sci 16:73 – 78