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Planta Med 2015; 81 - PP7
DOI: 10.1055/s-0035-1545224
DOI: 10.1055/s-0035-1545224
Indole alkaloids from plants: Novel structures, bioactivities and preclinical investigations
Monoterpenoid Indole Alkaloids (MIAs) account for an important group of natural products. Both their highly complex chemical structures and pronounced pharmacological activities have made research on alkaloids, including elucidation of their biosynthetic pathways, very attractive for many decades.
We have reported novel indole alkaloids from plants, of which four showed significant antitumor activity in vitro and in vivo. Moreover, preclinical investigation of indole alkaloids from Alstonia. scholari has been carried out. Fortunately, an investigational new drug (IND) of total indole alkaloids has been approved for clinical trials to treat respiratory diseases (phase I and II) by SFDA of China in 2011.