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Synthesis 2016; 48(02): 271-280
DOI: 10.1055/s-0035-1560754
DOI: 10.1055/s-0035-1560754
paper
A Facile Linking of the Pyrrole Ring with Functionalized 3(2H)-Furanone Moieties
Authors
Further Information
Publication History
Received: 02 August 2015
Accepted after revision: 24 September 2015
Publication Date:
29 October 2015 (online)
Abstract
The CN-functionalized pyrrole(indole)-3(2H)-furanone derivatives are readily synthesized via the domino reaction of diverse pyrrole(indole) carboxylic acids with tertiary cyanopropargylic alcohols (Et3N, MeCN, MW reactor, 100 °C, 1.2 atm) in up to 93% yield.
Key words
pyrrole(indole)-2-carboxylic acids - tertiary cyanopropargylic alcohols - domino reaction - cyclization - pyrrole(indole)-3(2H)-furanone derivativesSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560754.
- Supporting Information (PDF) (opens in new window)
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