Cascade Oxa-Michael–Henry Reaction of Salicylaldehydes with Nitrostyrenes via Ball Milling: A Solvent-Free Synthesis of 3-Nitro-2H-chromenes

Abstract

Cascade oxa-Michael–Henry reactions of salicylaldehyde derivatives with β-nitrostyrenes catalyzed by potassium carbonate via solvent-free ball milling are demonstrated. The corresponding 3-nitro-2H-chromene products were obtained in moderate to excellent yields. This method offers significant advantages, particularly in terms of high yields, short reaction times and mild conditions.

Key words

solvent-free - ball milling - cascade - oxa-Michael–Henry reaction - 3-nitro-2H-chromenes

• References

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