Synthesis 2016; 48(14): 2280-2286
DOI: 10.1055/s-0035-1561422
paper
© Georg Thieme Verlag Stuttgart · New York

The Application of Multicomponent Ugi and Passerini Reactions for the One-Pot Synthesis of Pyrrolones and Butenolides

Anton A. Nechaev
a  Laboratory of Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001 Leuven, Belgium   Email: [email protected]
,
Anatoly A. Peshkov
a  Laboratory of Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001 Leuven, Belgium   Email: [email protected]
,
Vsevolod A. Peshkov*
b  College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Dushu Lake Campus, Suzhou, 215123, P. R. of China   Email: [email protected]
,
Erik V. Van der Eycken*
a  Laboratory of Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001 Leuven, Belgium   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 26 January 2016

Accepted after revision: 29 February 2016

Publication Date:
12 April 2016 (online)


Abstract

A new protocol for the one-pot synthesis of pyrrolones and butenolides involving an isocyanide-based multicomponent reaction (Ugi or Passerini) followed by a triethylamine-promoted cycloisomerization is described.

Supporting Information

 
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  • 1 These authors contributed equally to this work.
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