Synthesis 2016; 48(21): 3713-3718
DOI: 10.1055/s-0035-1562436
paper
© Georg Thieme Verlag Stuttgart · New York

Facile Synthesis of N-Substituted Benzimidazoles

Santosh Kurhade
University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands   Email: a.s.s.domling@rug.nl
,
Arianna Rossetti
University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands   Email: a.s.s.domling@rug.nl
,
Alexander Dömling
University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands   Email: a.s.s.domling@rug.nl
› Author Affiliations
Further Information

Publication History

Received: 21 April 2016

Accepted after revision: 04 May 2016

Publication Date:
23 June 2016 (online)


Abstract

A particularly mild and efficient one-pot synthesis of N-substituted benzimidazole derivatives was developed. 2-Fluoro-5-nitrophenylisocyanide reacts with a diverse set of primary amines to afford the respective products in moderate to very good yield (35–95%; 20 examples).

Supporting Information

 
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