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DOI: 10.1055/s-0035-1565506
Studies on the chemical constituent and bioactivities of Pandanus amaryllifolius
Pandanus amaryllifolius Roxb. (Pandanaceae) is a tropical shrub that distributed in Southeast Asia, and was introduced to Taiwan as a cultivated plant from Vietnam in 1980's. In Vietnam, Thailand, Indonesia and Malaysia, the plant is popular as a kind of spices and folk medicine for the treatment of hyperglycemia, hypertension and cancer.
In a previous study, the ethanolic extract of P. amaryllifolius aerial part showed potential antioxidant, anti-biofilm and anti-inflammatory activities. This extract was separated by an acid-base extraction method to give an alkaloid-containing fraction. Three new compounds designated pandamarine B (1) and pandalizines C and D (2 and 3) were isolated from the alkaloid-containing fraction. All of the structures were elucidated by spectroscopic analysis, and were classified into two skeletons, pandamarilactones (1), indolizinones (2 and 3).
In literature reports, the alkaloid-rich fraction from P. amaryllifolius showed antioxidant activity. However, all alkaloids in our investigation were inactive in anti-biofilm, anti-inflammatory, anti-platelet aggregation and cytotoxic assays.