Planta Med 2015; 81 - PM_129
DOI: 10.1055/s-0035-1565506

Studies on the chemical constituent and bioactivities of Pandanus amaryllifolius

HC Hu 1, YB Cheng 1, 2, FR Chang 1, 2, 3, 4
  • 1Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
  • 2Research Center for Natural Products and Drug Development, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  • 3Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  • 4Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan

Pandanus amaryllifolius Roxb. (Pandanaceae) is a tropical shrub that distributed in Southeast Asia, and was introduced to Taiwan as a cultivated plant from Vietnam in 1980's. In Vietnam, Thailand, Indonesia and Malaysia, the plant is popular as a kind of spices and folk medicine for the treatment of hyperglycemia, hypertension and cancer.

In a previous study, the ethanolic extract of P. amaryllifolius aerial part showed potential antioxidant, anti-biofilm and anti-inflammatory activities. This extract was separated by an acid-base extraction method to give an alkaloid-containing fraction. Three new compounds designated pandamarine B (1) and pandalizines C and D (2 and 3) were isolated from the alkaloid-containing fraction. All of the structures were elucidated by spectroscopic analysis, and were classified into two skeletons, pandamarilactones (1), indolizinones (2 and 3).

In literature reports, the alkaloid-rich fraction from P. amaryllifolius showed antioxidant activity. However, all alkaloids in our investigation were inactive in anti-biofilm, anti-inflammatory, anti-platelet aggregation and cytotoxic assays.