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DOI: 10.1055/s-0035-1565579
In vitro biological evaluation of polyurethane microstructures genistein based formulation
Natural products provide a wide range of active agents for an increased number of pathologies. World Health Organization (WHO) reports that a percentage of 60% to 80% of population call for natural medicine in case of primary healthcare needs [1]. The isoflavone genistein (4',5,7-trihydroxyisoflavone) is an example of natural compound included in both preclinical and clinical tests for anti-osteoporotic, cardio-protective, photo-protective, anti-inflammatory, antioxidant and anti-cancer properties [2]. Polyurethane microstructure can offer: (1) protection of the biologically active compound to external agents (UV radiation, strong acidic or alkaline environments, etc. (2) the possibility of amending the lipo- or water-solubility of encapsulated compounds, (3) drug delivery targeted to a specific receptor, (4) retarded activity of the encapsulated drug by the use of transport vehicles having low speed of degradation [3, 4]. Since finding such a formulation for genistein could improve its applications, we have conducted a preliminary study regarding the in vitro antiproliferative (MCF7, MDA-MB-231 and T47D) and antimicrobial (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis (D), Bacillus subtilis, Bacillus cereus, and Candida albicans) activity in order to test whether polyurethane microstructures represent a good option for further modulation of genistein's bioavailability. The study concludes that polyurethane microstructures represent a bad in vitro partner for the isoflavone genistein.
Acknowledgement: The study was financed by the UMFT grant -Parteneriate în cercetarea fundamentală inovativă-PIII-C2-PCFI-2015/2016 acronim FLAVOFORM.
References:
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