Planta Med 2016; 82 - PA24
DOI: 10.1055/s-0036-1578639

The Pharmacokinetics Of Dihydromyricetin In Dogs

ZQ Wang 1, XH Wang 2, XQ Wang 1, S Li 1, R Zeng 1, B Wang 1, ZH Peng 2, LF Cheng 2
  • 1School of Pharmaceutical Science, Department of Pharmacology, Hunan University of Chinese Medicine, Changsha, China
  • 2Institute of Chinese Material Medical, Hunan Academy of Chinese Medicine, Changsha, China

Dihydromyricetin (Figure 1) is the main flavonoid compound in ampelopsis großedentata and exists in many natural plants. To date, only rare methods and pharmacokinetic studies of dihydromyricetin have been reported [1]. To study the pharmacokinetics of dihydromyricetin, beagle dogs were treated by orally at different doses and the RP-HPLC-UV method is used to determine dihydromyricetin in the plasma. The pharmacokinetic parameters are calculated by Pharmacokinetic Module of DAS2.1 software. The study confirmed that temperature is the key factor affects the stability of dihydromyricetin in plasma and built a sensitive and accurate RP-HPLC-UV method for the quantitative determination of dihydromyricetin in biosamples. The results show that the pharmacokinetics of dihydromyricetin in dogs is coincident with the two-compartmental model with great individual variance, the oral administration including single-dose (at 37.5, 75, 150 mg/kg), multiple-dose of 150 mg/kg and the repeated daily administration at the dose of 100 mg/kg, 500 mg/kg and 2,500 mg/kg last for 90 days.

Fig. 1: The chemical structure of DMY

Acknowledgements: The support for this research from the Science Foundation of Hunan Province Education Department (No. [2012]402 – 189) and Hunan Province Science and Technology Foundation (No. 2011TF2008) are gratefully acknowledged.

References: [1] Zhang YS, Zhang QY, et al. (2007) Journal of Chromatography. B, 860(1): 4 – 9.