Copper-Catalyzed Asymmetric 1,2-Addition of Grignard Reagents to 3-Acyl 2H-chromenesFinancial support from The Netherlands Organization for Scientific Research (NWO-CW) is acknowledged.
Received: 09 June 2017
Accepted after revision: 10 July 2017
17 August 2017 (eFirst)
Enones in which the carbon–carbon double bond is part of the pharmacologically important 2H-chromene (2H-1-benzopyran) nucleus undergo asymmetric copper-catalyzed 1,2-addition of Grignard reagents. High yields and enantiomeric excesses up to 84% are obtained and access to these novel enantio-enriched tertiary alcohols is provided.