Synlett
DOI: 10.1055/s-0036-1588532
letter
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed Asymmetric 1,2-Addition of Grignard Reagents to 3-Acyl 2H-chromenes

Beatriz C. Calvo, Adriaan J. Minnaard*
  • Stratingh Institute for Chemistry, Nijenborgh 7, 9747 AG Groningen, The Netherlands   Email: a.j.minnaard@rug.nl
Financial support from The Netherlands Organization for Scientific Research (NWO-CW) is acknowledged.
Further Information

Publication History

Received: 09 June 2017

Accepted after revision: 10 July 2017

Publication Date:
17 August 2017 (eFirst)

Abstract

Enones in which the carbon–carbon double bond is part of the pharmacologically important 2H-chromene (2H-1-benzopyran) nucleus undergo asymmetric copper-catalyzed 1,2-addition of Grignard reagents. High yields and enantiomeric excesses up to 84% are obtained and access to these novel enantio-enriched tertiary alcohols is provided.

Supporting Information