Safe and Convenient Synthesis of Primary N-Nitramines in the Freon Media

Abstract

A convenient one-pot synthesis of primary aliphatic N-nitramines, which includes the nitration of available N,N′-dialkyloxalamides or N-alkylcarbamates with dinitrogen pentoxide in the 1,1,1,2-tetrafluoroethane media followed by ammonolysis of intermediate N-nitroamides in the same solvent has been developed. The method is environmentally safe, and affords target N-nitramines in up to 94% overall yield.

Key words

nitration - dinitrogen pentoxide - nitramides - nitramines - 1,1,1,2-tetrafluoroethane

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