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Synthesis 2017; 49(12): 2768-2774
DOI: 10.1055/s-0036-1588752
DOI: 10.1055/s-0036-1588752
paper
First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine
Authors
Further Information
Publication History
Received: 02 January 2017
Accepted after revision: 24 February 2017
Publication Date:
17 March 2017 (online)
Abstract
A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of a vicarious nucleophilic substitution in the total synthesis of a cytotoxic aaptamine derivative.
Key words
total synthesis - heterocycles - vicarious aromatic substitution - cyclization - alkylationSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588752.
- Supporting Information (PDF) (opens in new window)
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