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Synthesis 2017; 49(18): 4299-4302
DOI: 10.1055/s-0036-1588857
DOI: 10.1055/s-0036-1588857
paper
Synthesis of l-Ribose from d-Ribose by a Stereoconversion through Sequential Lactonization as the Key Transformation
Authors
Further Information
Publication History
Received: 14 April 2017
Accepted after revision: 08 May 2017
Publication Date:
20 June 2017 (online)
‡ These authors contributed equally to this work.
Abstract
l-Ribose, a key precursor of various l-nucleosides can only be synthesized from other sugars or other non-sugar precursors. Herein, the study involves the synthesis of naturally rare l-ribose from readily available d-ribose. Though, many synthetic strategies are developed to meet the increasing demands of l-ribose, seeking innovation, a synthesis employing sequential lactonization as the key transformation was explored. This novel conversion involves protection, oxidation, sequential lactonization, reduction with DIBAL-H, and deprotection.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588857.
- Supporting Information (PDF)
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