Rhodium-Catalyzed Reductive Cleavage of Aryl Carbamates Using Isopropanol as a ReductantThis work was supported by ACT-C (JPMJCR12ZF) from JST, Japan and Scientific Research on Innovative Area ‘Precisely Designed Catalysts with Customized Scaffolding’ (16H01022) from MEXT, Japan. K.Y. thanks JSPS Research Fellowship for Young Scientists.
Received: 31 May 2017
Accepted after revision: 10 July 2017
17 August 2017 (eFirst)
Published as part of the Cluster C–O Activation
Despite the widespread use of carbamates as a directing group in C–H bond-functionalization reactions, reductive removal of this directing group is not straightforward. Currently available methods are limited to nickel-catalyzed reactions using i PrMgX or hydrosilane as a reductant, leaving the functional group compatibility issue to be solved. Herein, we report rhodium-catalyzed reductive cleavage of aryl carbamates using iPrOH as a milder reductant.