Iodobenzene-Promoted Pd-Catalysed ortho-Directed C–H Activation: The Synthesis of Benzothiazoles via Intramolecular CouplingSupported by: We acknowledge financial support from: National Natural Science Foundation of China (21302150)
Supported by: Hubei Provincial Department of Education (D20131501)
Supported by: Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry 1707
Supported by: President Foundation of Wuhan Institute of Technology (2014038)
Supported by: Foundation of ChutianDdistinguished Fellow from Hubei Provincial Department of Education, Foundation of High-end Talent Cultivation Program from Wuhan Institute of Technology.
Received: 08 February 2017
Accepted after revision: 01 March 2017
16 March 2017 (online)
A series of 2-aminobenzothiazoles were synthesized by a palladium-catalysed oxidative coupling with good yields (62–89%). Iodobenzene was found to be effective as an additive in this intramolecular C–S bond-formation reaction. The directing thiourea group attached to the aryl ring is essential for the activation of the ortho C–H bond.