Triflic Anhydride Promoted Intramolecular Cyclization of N-Aryl Cinnamides: Access to Polysubstituted Quinolin-2(1H)-onesFinancial support of this research by the National Natural Science Foundation of China (21502185, 21172211 and 21542006) is gratefully acknowledged.
Received: 24 April 2017
Accepted after revision: 05 June 2017
02 August 2017 (eFirst)
A facile and efficient synthesis of polysubstituted quinolin-2(1H)-ones is developed via intramolecular cyclization of readily available N-aryl cinnamides promoted by triflic anhydride in N,N-dimethyl trifluoroacetamide (DTA) under mild conditions.