DOI: 10.1055/s-0036-1590821
© Georg Thieme Verlag Stuttgart · New York

Triflic Anhydride Promoted Intramolecular Cyclization of N-Aryl Cinnamides: Access to Polysubstituted Quinolin-2(1H)-ones

Qian Zhang, Jingwen Yuan, Mangfei Yu, Rui Zhang*, Yongjiu Liang, Peng Huang, Dewen Dong*
  • Jilin Province Key Laboratory of Green Chemistry and Process, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P. R. of China   Email:   Email:
Financial support of this research by the National Natural Science Foundation of China (21502185, 21172211 and 21542006) is gratefully acknowledged.
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Publication History

Received: 24 April 2017

Accepted after revision: 05 June 2017

Publication Date:
02 August 2017 (eFirst)


A facile and efficient synthesis of polysubstituted quinolin-2(1H)-ones is developed via intramolecular cyclization of readily available N-aryl cinnamides promoted by triflic anhydride in N,N-dimethyl trifluoroacetamide (DTA) under mild conditions.

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