DOI: 10.1055/s-0036-1590838
© Georg Thieme Verlag Stuttgart · New York

Ether Synthesis through Reductive Cross-Coupling of Ketones with Alcohols Using Me2SiHCl as both Reductant and Lewis Acid

Yong Ho Lee, Bill Morandi*
  • Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany   Email:
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Publication History

Received: 05 May 2017

Accepted after revision: 20 June 2017

Publication Date:
20 July 2017 (eFirst)

Published as part of the Cluster Silicon in Synthesis and Catalysis


We report that a Lewis acidic silane, Me2SiHCl, can mediate the direct cross-coupling of a wide range of carbonyl compounds with alcohols to form dialkyl ethers. The reaction is operationally simple, tolerates a range of polar functional groups, can be utilized to make sterically hindered ethers, and is extendable to sulfur and nitrogen nucleo­philes.

Supporting Information