Enantioselective Palladium-Catalyzed Decarboxylative Allylation of β-Keto Esters Assisted by a ThioureaWe are grateful for a start-up fund from the South University of Science and Technology of China (to X. Zhang), and the National Natural Science Foundation of China (21672096) (to L. W. Chung) and the Shenzhen Science and Technology Innovation Committee (KQTD20150717103157174) (to X. Zhang and L. W. Chung) for financial support.
Received: 16 June 2017
Accepted after revision: 18 July 2017
22 August 2017 (eFirst)
‡ These two authors contributed equally to this work
Enantioselective intramolecular decarboxylative allylation of β-keto esters catalyzed by a palladium bis(phosphine)-thiourea complex is reported. This procedure is not only effective for β-keto esters, but also effective for β-keto amides. An intermolecular variant of the asymmetric decarboxylative allylation is also established. DFT calculations indicate that an outer-sphere mechanism is viable for the decarboxylative allylation of β-keto esters.