DOI: 10.1055/s-0036-1590917
© Georg Thieme Verlag Stuttgart · New York

Metal-Free Mild Synthesis of Novel 1′H-Spiro[Cycloalkyl-1,2′-quinazolin]-4′(3′H)-ones by an Organocatalytic Cascade Reaction

Rathinam Ramesha, Periyathambi Kalisamya, Jan Grzegorz Maleckib, Appaswami Lalitha*a
  • aDepartment of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem-636011, Tamil Nadu, India
  • bDepartment of Crystallography, University of Silesia, Szkolna 9, 40-006 Katowice, Poland   Email:
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Publication History

Received: 15 August 2017

Accepted after revision: 05 September 2017

Publication Date:
26 September 2017 (eFirst)


A concise organocatalytic method for the facile synthesis of some novel 1′H-spiro[cycloalkyl-1,2′-quinazolin]-4′(3′H)-ones via a one-pot, three-component condensation of isatoic anhydride, aryl or aliphatic amines and a cyclic ketone is described.

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