C(sp³)–H Peroxidation of 3-Substituted Indolin-2-ones under Metal-Free Conditions

^◊ These authors contributed equally to this work

Abstract

A C(sp³)–H peroxidation of 3-substituted indolin-2-ones through radical coupling reaction has been developed under metal-free conditions. Using tert-butyl hydroperoxide both as an oxidant and as a peroxidation reagent to couple with the C(sp³)–H bonds of 3-substituted indolin-2-ones can form a new C–O bond without using any additives. This simple strategy provides a green and efficient approach to 3-peroxyindolin-2-ones in moderate to excellent yields. The resulting 3-peroxyindolin-2-ones could be further transformed into 3-hydroxy­indolin-2-ones.

Key words

C(sp³)–H peroxidation - metal-free - 3-substituted indolin-2-ones - tert-butyl hydroperoxide

• References and Notes

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