Topical anti-inflammatory activity of the hydroethanolic extract from Kalanchoe brasiliensis Cambess. (Crassulaceae) leaves
24. Oktober 2017 (online)
Kalanchoe brasiliensis Cambess. (Crassulaceae), known as “saião”, is a plant used in folk medicine for the treatment of inflammation, injuries, abscesses, and enlarged ganglia.1,2 The present study evaluated the topical anti-inflammatory effect of the hydroethanolic extracts EHJ50 (50%) and EHJ70 (70%) obtained from K. brasiliensis leaves. Using doses of 0.10, 0.50 and 1.0 mg/ear of the extracts, the anti-inflammatory activity was assessed by Croton oil-induced acute ear edema method3, determination of inflammatory enzymes (MPO and NAG) and proinflammatory mediators (NO, IL-6 and TNF-α) and histopathological analysis. After 24h of treatment with EHJ50 and EHJ70, the inhibition of ear edema ranged from 62.03 to 80.34%. These extracts also reduced MPO (55.27 to 81.74%) and NAG (69.04 to 80.82%), while the NO levels decreased from 46.74 to 67.43%. The dose of 1.0 mg/ear was able to inhibit IL-6 (EHJ50 = 20.59% and EHJ70 = 22.78%) and TNF-α (EHJ50 = 16.71% and EHJ70 = 23.71%). These results suggest that K. brasiliensis has topical anti-inflammatory effect and can be a promising source for the development of phytotherapics for skin disorders.
This investigation was supported by UFJF, FAPEMIG, CAPES, OEA and GCUB.
 Costa SS, Jossang A, Bodo B, Souza ML, Moraes VL. J Nat Prod 1994; 57: 1503 – 1510.
 Mourão RH, Santos FO, Franzotti EM, Moreno MP, Antoniolli AR. Phytother Res 1999; 13: 352 – 354.
 Schiantarelli P, Cadel S, Acerbi D, Pavesi L. J Drug Res1982; 32:230-235.