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Synthesis 2018; 50(10): 2067-2075
DOI: 10.1055/s-0037-1609301
DOI: 10.1055/s-0037-1609301
paper
Palladium-Catalyzed Germylation of Aryl Bromides and Aryl Triflates Using Hexamethyldigermane
This work was supported in part by JSPS KAKENHI Grant Number JP15H05802 in Precisely Designed Catalysts with Customized Scaffolding.Further Information
Publication History
Received: 12 December 2017
Accepted after revision: 16 January 2018
Publication Date:
14 February 2018 (online)
Abstract
Palladium-catalyzed germylation of aryl bromides and aryl triflates using commercially available hexamethyldigermane is described. Optimized reaction conditions afforded various functionalized aryltrimethylgermanes, including drug-like molecules, in moderate to good yields, demonstrating the versatility of the presented protocols.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609301.
- Supporting Information
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Cross-coupling reactions of arylgermane derivatives: