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Synthesis 2018; 50(17): 3487-3492
DOI: 10.1055/s-0037-1610124
DOI: 10.1055/s-0037-1610124
paper
Rhodium-Catalyzed Annulation of 2-Arylimidazoles and α-Aroyl Sulfoxonium Ylides toward 5-Arylimidazo[2,1-a]isoquinolines
We thank the National Natural Science Foundation of China (No. 21572025, 21602019, and 21672028), ‘Innovation & Entrepreneurship Talents’ Introduction Plan of Jiangsu Province, Natural Science Foundation of Jiangsu Province (BK20171193), the Key University Science Research Project of Jiangsu Province (15KJA150001), Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology (BM2012110), and Advanced Catalysis and Green Manufacturing Collaborative Innovation Center for financial support. Sun thanks Young Natural Science Foundation of Jiangsu Province (BK20150263) for financial support.Further Information
Publication History
Received: 04 April 2018
Accepted after revision: 17 May 2018
Publication Date:
28 June 2018 (online)
Abstract
A Rh-catalyzed annulation between 2-aryl-1H-benzo[d]imidazoles and α-aroyl sulfoxonium ylides was developed, affording a series of benzimidazo[2,1-a]isoquinolines in moderate to excellent yields. This procedure proceeded with the sequential ortho-C–H functionalization and cyclization, representing a facile and straightforward pathway to access such frameworks.
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For reviews, see:
For recent typical reports on the insertion of X–H bond to metal carbenes, see: