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CC BY ND NC 4.0 · Synthesis 2019; 51(01): 240-250
DOI: 10.1055/s-0037-1610378
DOI: 10.1055/s-0037-1610378
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Alkylpotassium-Catalyzed Benzylic C–H Alkylation of Alkylarenes with Alkenes
Authors
This work was partially supported by ACT-C, JST, and AMED (S.K.), and JSPS KAKENHI Grant Number JP 17H06448 (Y.Y.). I.S. thanks JSPS Research Fellowships for Young Scientists and MERIT program, The University of Tokyo, for financial support.
Further Information
Publication History
Received: 17 October 2018
Accepted: 18 October 2018
Publication Date:
26 November 2018 (online)
Published as part of the 50 Years SYNTHESIS – Golden Anniversary Issue
Abstract
Catalytic benzylic C–H alkylation reactions of alkylarenes with alkenes such as β-substituted styrenes and vinylsilanes have been achieved by utilizing alkylpotassium as a catalyst. Various substituted toluene derivatives can be alkylated under mild reaction conditions to afford the desired functionalized hydrocarbons in moderate to high yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610378.
- Supporting Information (PDF)
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For selected examples, see:
For selected examples of Strong Brønsted base catalyzed addition reactions with styrenes, see: