Amer J Perinatol 2018; 35(08): 748-757
DOI: 10.1055/s-0037-1615285
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Estimated Placental Volume and Gestational Age

Kimberly M. M. Isakov
1  School of Medicine, Yale University, New Haven, Connecticut
,
John W. Emerson
2  Department of Statistics, Yale University, New Haven, Connecticut
,
Katherine H. Campbell
3  Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut
,
France Galerneau
3  Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut
,
Amber M. Anders
1  School of Medicine, Yale University, New Haven, Connecticut
,
Yoonjoo K. Lee
4  School of Medicine, Boston University, Boston, Massachusetts
,
Pritha Subramanyam
5  Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
,
Andrea E. Roberts
1  School of Medicine, Yale University, New Haven, Connecticut
,
Harvey J. Kliman
3  Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut
› Author Affiliations
Funding This study was funded by Reproductive and Placental Research Unit, Yale University School of Medicine.
Further Information

Publication History

10 April 2017

10 November 2017

Publication Date:
27 December 2017 (eFirst)

Abstract

Objective The objective of this study was to validate estimated placental volume (EPV) across a range of gestational ages (GAs).

Study Design Three hundred sixty-six patients from 2009 to 2011 received ultrasound scans between 11 + 0 and 38 + 6 weeks GA to assess EPV. An EPV versus GA best fit curve was generated and compared with published normative curves of EPV versus GA in a different population. A subanalysis was performed to explore the relationship between EPV and birth weight (BW).

Results Analysis of EPV versus GA revealed a parabolic curve with the following best fit equation: EPV = (0.372 GA − 0.00364 GA2)3. EPV was weakly correlated with BW, and patients with an EPV in the bottom 50th percentile had 2.42 times the odds of having a newborn with a BW in the bottom 50th percentile (95% confidence interval: 1.27–4.68). Microscopic evaluation of two placentas corresponding to the smallest EPV outliers revealed significant placental pathology.

Conclusion Placental volume increases throughout gestation and follows a predictable parabolic curve, in agreement with the existing literature. Further validation is required, but EPV may have the potential for clinical utility as a screening tool in a variety of settings.