Estimated Placental Volume and Gestational Age
10 April 2017
10 November 2017
27 December 2017 (eFirst)
Objective The objective of this study was to validate estimated placental volume (EPV) across a range of gestational ages (GAs).
Study Design Three hundred sixty-six patients from 2009 to 2011 received ultrasound scans between 11 + 0 and 38 + 6 weeks GA to assess EPV. An EPV versus GA best fit curve was generated and compared with published normative curves of EPV versus GA in a different population. A subanalysis was performed to explore the relationship between EPV and birth weight (BW).
Results Analysis of EPV versus GA revealed a parabolic curve with the following best fit equation: EPV = (0.372 GA − 0.00364 GA2)3. EPV was weakly correlated with BW, and patients with an EPV in the bottom 50th percentile had 2.42 times the odds of having a newborn with a BW in the bottom 50th percentile (95% confidence interval: 1.27–4.68). Microscopic evaluation of two placentas corresponding to the smallest EPV outliers revealed significant placental pathology.
Conclusion Placental volume increases throughout gestation and follows a predictable parabolic curve, in agreement with the existing literature. Further validation is required, but EPV may have the potential for clinical utility as a screening tool in a variety of settings.
This study was funded by Reproductive and Placental Research Unit, Yale University School of Medicine.
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