A New Synthetic Pathway to Symmetric Bisubstituted Naphthoquinones

Abstract

straightforward and practical synthesis of 2,3-diiodo-1,4-naphthoquinone is reported. Based on the prepared diiodide, a new synthetic approach to symmetric bisubstituted 1,4-naphthoquinones via double Suzuki–Miyaura reaction at room temperature has been researched and developed. The presented general method combines broad-spectrum applicability, efficiency, and simplicity providing target materials in good to quantitative yields.

Key words

1,4-naphthoquinone - Finkelstein reaction - Suzuki–Miyaura reaction - Pd catalysis - pinacolboronic esters

• References

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