Visible-Light-Promoted C2 Trifluoromethylation of Quinoline N-Oxides

Abstract

A photoredox catalytic strategy has been described for the direct C2 trifluoromethylation of quinoline N-oxides. This reaction is compatible with a range of synthetically relevant functional groups for providing efficient synthesis of a variety of C2 trifluoromethyl quinoline N-oxides at room temperature. Mechanistic studies indicated that the reaction proceeds via a radical pathway.

Key words

trifluoromethylation - photoredox - C–H functionlization - radicals - N-oxide compounds

• References

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