An iodine-catalyzed [3+2]-cycloaddition reaction of substituted benzylidenemalononitriles
and ethyl glycinate hydrochloride in DMF has been developed for the synthesis of 5-amino-1H-pyrrole-2-carboxylates. This efficient method provides access to a variety of structurally
diverse pyrrole-2-carboxylate derivatives. The structure of a typical product was
confirmed by X-ray crystallography.
Key words
[3+2]-cycloaddition - ethyl glycinate hydrochloride - benzylidenemalononitrile - aminopyrrolecarboxylates
- aromatization