Eur J Pediatr Surg 2021; 31(03): 226-235
DOI: 10.1055/s-0040-1713663
Original Article

Outcome of Very Low and Low Birth Weight Infants with Esophageal Atresia: Results of the Turkish Esophageal Atresia Registry

1   Department of Pediatric Surgery, Izmir Katip Celebi University, Izmir, Turkey
2   Department of Pediatric Surgery, Hacettepe University, Ankara, Turkey
3   Department of Pediatric Surgery, Ankara Yildirim Beyazit Universitesi, Ankara, Turkey
Binali Firinci
4   Department of Pediatric Surgery, Ataturk University, Erzurum, Turkey
Çiğdem U. Durakbaşa
5   Department of Pediatric Surgery, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey
Zafer Dokumcu
6   Department of Pediatric Surgery, Ege University, Izmir, Turkey
Gulnur Gollu
7   Department of Pediatric Surgery, Ankara University, Ankara, Turkey
Ibrahim Akkoyun
8   Department of Pediatric Surgery, Konya Education and Research Hospital, Konya, Turkey
Dilek Demirel
9   Department of Pediatric Surgery, Ondokuz Mayıs University, Samsun, Turkey
Ayşe Karaman
10   Department of Pediatric Surgery, Dr. Sami Ulus Maternity and Children Health and Research Application Center, University of Health Sciences, Ankara, Turkey
Ilhan Ciftci
11   Department of Pediatric Surgery, Selçuk University, Konya, Turkey
Huseyin Ilhan
12   Department of Pediatric Surgery, Eskisehir Osmangazi University, Eskisehir, Turkey
Ayse Parlak
13   Department of Pediatric Surgery, Uludag University, Bursa, Turkey
Onder Ozden
14   Department of Pediatric Surgery, Cukurova University, Adana, Turkey
Hatice S. Y. Cömert
15   Department of Pediatric Surgery, Karadeniz Technical University, Trabzon, Turkey
Akgun Oral
16   Department of Pediatric Surgery, Dr. Behcet Uz Education and Research Hospital, Izmir, Turkey
Gonca Tekant
17   Department of Pediatric Surgery, Istanbul University-Cerrahpasa, Istanbul, Istanbul, Turkey
Gursu Kiyan
18   Department of Pediatric Surgery, Marmara University, Istanbul, Turkey
Başak Erginel
19   Department of Pediatric Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Unal Guvenc
20   Department of Pediatric Surgery, Kanuni Sultan Suleyman Education and Research Hospital, Istanbul, Turkey
Ali Onur Erdem
21   Department of Pediatric Surgery, Adnan Menderes University, Aydin, Turkey
Nazile Erturk
22   Department of Pediatric Surgery, Mugla Sitki Kocman University Ringgold standard institution, Mugla, Turkey
Abdullah Yildiz
23   Department of Pediatric Surgery, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey
› Author Affiliations
Funding None.


Introduction The data of the Turkish Esophageal Atresia Registry (TEAR) was evaluated to define the outcome of very low birth weight (VLBW) and low BW (LWB) infants with esophageal atresia (EA).

Materials and Methods The data registered by 24 centers between 2014 and 2018 were evaluated for demographic features, prenatal findings, associated anomalies, surgical treatment, and outcome. Patients were enrolled in three groups according to their BWs (VLBW <1,500 g), LWB = 1,500–2,500 g), and normal BW (NBW; >2,500 g).

Results Among the 389 cases, there were 37 patients (9.5%) in the VLBW group, 165 patients (42.4%) in the LBW group, and 187 patients (48.1%) in the NBW group. Prenatal diagnosis rates were similar among the three groups (29.7, 34.5, and 24.6%, respectively). The standard primary anastomosis was achieved at a significantly higher rate in NWB cases than in the other groups (p < 0.05). In patients with tracheoesophageal fistula (TEF), patients of the NBW group had significantly higher rates of full oral feedings, when compared with VLBW and LBW cases (p < 0.05). At the end of the first year, when we evaluate all patients, the number of cases with fistula recanalization and esophageal anastomotic strictures (AS) requiring esophageal dilatation was similar among the groups. The weight and height measurements at 6 months and 1 year of age of the survivors were similar in all the groups. The overall mortality rate was significantly higher in the VLBW and LBW groups, when compared with the NBW patients, even in patients with tension-free anastomosis (p < 0.05). The incidence of the associated anomalies was 90.6% in cases with mortality, which was significantly higher than in survivors (59.6%; p < 0.05). According to Spitz's classification, the survival rate was 87.1% in class I, 55.3% in class II, and 16.7% in class III. The most common causes of mortality were associated with cardiovascular diseases, pneumonia, and sepsis.

Conclusion The national data of TEAR demonstrates that the developmental and feeding parameters are better in NBW patients. Although VLBW patients have higher risk of developing fistula canalization than the LBW and NBW groups, long-term complications, such as anastomotic strictures, weight, and height values, after 1 year are similar in both groups. According to our results, associated anomalies and LBWs are still significant risk factors for mortality in cases with EA.

Publication History

Received: 15 January 2020

Accepted: 19 May 2020

Publication Date:
06 July 2020 (online)

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