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Synthesis 2022; 54(07): 1775-1784
DOI: 10.1055/s-0040-1719841
paper

Facile Synthesis of Quaternary α-Fluoronitriles by Cobalt-Catalyzed Hydrocyanation of Monofluoroalkenes

Yanlin Li
,
Ru Cui
,
Tian-Rui Wu
,
Xi-Sheng Wang  ∗
We gratefully acknowledge the National Science Foundation of China (21971228, 21772187) for financial support.
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Abstract

An exclusively regioselective hydrocyanation of monofluoroalkenes has been developed, with which a series of aliphatic quaternary α-fluoronitriles were synthesized in a facile and efficient manner. This novel method is featured with mild conditions, good functional groups compatibilities, and high reactivity.

Key words

quaternary α-fluoronitriles - hydrocyanation - monofluoroalkenes - cobalt catalysis - radical

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1719841.
  • Supporting Information


Publication History

Received: 16 August 2021

Accepted after revision: 07 September 2021

Article published online:
21 October 2021

© 2021. Thieme. All rights reserved

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