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Synthesis 2022; 54(07): 1775-1784
DOI: 10.1055/s-0040-1719841
DOI: 10.1055/s-0040-1719841
paper
Facile Synthesis of Quaternary α-Fluoronitriles by Cobalt-Catalyzed Hydrocyanation of Monofluoroalkenes
We gratefully acknowledge the National Science Foundation of China (21971228, 21772187) for financial support.
Abstract
An exclusively regioselective hydrocyanation of monofluoroalkenes has been developed, with which a series of aliphatic quaternary α-fluoronitriles were synthesized in a facile and efficient manner. This novel method is featured with mild conditions, good functional groups compatibilities, and high reactivity.
Key words
quaternary α-fluoronitriles - hydrocyanation - monofluoroalkenes - cobalt catalysis - radicalSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1719841.
- Supporting Information
Publikationsverlauf
Eingereicht: 16. August 2021
Angenommen nach Revision: 07. September 2021
Artikel online veröffentlicht:
21. Oktober 2021
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