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Synthesis 2022; 54(07): 1775-1784
DOI: 10.1055/s-0040-1719841
DOI: 10.1055/s-0040-1719841
paper
Facile Synthesis of Quaternary α-Fluoronitriles by Cobalt-Catalyzed Hydrocyanation of Monofluoroalkenes
Authors
We gratefully acknowledge the National Science Foundation of China (21971228, 21772187) for financial support.
Abstract
An exclusively regioselective hydrocyanation of monofluoroalkenes has been developed, with which a series of aliphatic quaternary α-fluoronitriles were synthesized in a facile and efficient manner. This novel method is featured with mild conditions, good functional groups compatibilities, and high reactivity.
Key words
quaternary α-fluoronitriles - hydrocyanation - monofluoroalkenes - cobalt catalysis - radicalSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1719841.
- Supporting Information (PDF)
Publication History
Received: 16 August 2021
Accepted after revision: 07 September 2021
Article published online:
21 October 2021
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