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Planta Med 2016; 82(08): 729-733
DOI: 10.1055/s-0042-102539
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

New Cytotoxic Tigliane Diterpenoids from Croton caudatus

Ying-Ying Chen   *
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, Peopleʼs Republic of China
2   University of Chinese Academy of Science, Beijing, Peopleʼs Republic of China
,
Kun-Xian Yang   *
3   First People Hospital of Yunnan Province, Kunming, Peopleʼs Republic of China
,
Xing-Wei Yang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, Peopleʼs Republic of China
,
Afsar Khan
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, Peopleʼs Republic of China
4   Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, Pakistan
,
Lu Liu
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, Peopleʼs Republic of China
2   University of Chinese Academy of Science, Beijing, Peopleʼs Republic of China
,
Bei Wang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, Peopleʼs Republic of China
2   University of Chinese Academy of Science, Beijing, Peopleʼs Republic of China
,
Yun-Li Zhao
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, Peopleʼs Republic of China
,
Ya-Ping Liu
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, Peopleʼs Republic of China
,
Yan Li
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, Peopleʼs Republic of China
,
Xiao-Dong Luo
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, Peopleʼs Republic of China
› Author Affiliations
Further Information

Publication History

received 11 September 2015
revised 06 January 2016

accepted 29 January 2016

Publication Date:
22 March 2016 (online)

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Abstract

Three new tigliane-type diterpenoids were isolated from the methanolic extract of the twigs and leaves of Croton caudatus, trivially named crotusins A–C (1–3). The structures of compounds 1–3 were elucidated on the basis of extensive spectral methods. These new compounds were highly oxygenated and heavily substituted. Cytotoxic activity against five human tumor cell lines was assessed for compounds 1–3 of which compound 3 showed significant inhibitory activity with IC50 values ranging from 0.49 to 4.19 µM against these cells, while crotusins A and B exhibited moderate activity.

Key words

Croton caudatus - Euphorbiaceae - tigliane diterpenoid - cytotoxic activity

* These authors contributed equally to this work.


Supporting Information

 

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