Synthesis 2024; 56(03): 435-444
DOI: 10.1055/s-0042-1751530
paper

Novel Two-Step Synthesis of N-Alkylated 2,3-Diaryl-4-quinolones

Alexander V. Aksenov
,
Nikolai A. Arutiunov
,
Anna M. Zatsepilina
,
Anna A. Aksenova
,
Elena V. Aleksandrova
,
Nicolai A. Aksenov
,
,
Dmitrii A. Aksenov
This work was supported by the Russian Science Foundation (grant #21-73-20051; https://rscf.ru/project/21-73-20051/).


Abstract

A library of 18 polysubstituted 4-quinolones was conveniently prepared via simple and practical protocol involving N-alkylation of 2-(3-oxoindolin-2-yl)acetonitriles and following NaH-induced ring expansion. The current two-step approach provides feasible access to a subclass of N-protected C3-aryl-substituted 2-phenyl-4-quinolones starting with or just one step away from commercially available 2-arylindoles and nitrostyrenes.

Supporting Information



Publication History

Received: 11 September 2023

Accepted after revision: 07 November 2023

Article published online:
06 December 2023

© 2023. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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