Short Lecture “Essential oil formulations for infectious diseases; a journey from basic research to antimicrobial validation of final product”

While antimicrobial investigations on essential oils abound within the literature, less attention has been given to neglected diseases, combinations, and the incorporation of antimicrobially active essential oils into formulations. This study focuses on these aspects by presenting data from three focus areas. The first study examines essential combinations against the causative pathogens of gas gangrene. Selected essential oils, were antimicrobially evaluated and Santalum austrocaledonicum displayed the lowest minimum inhibitory concentration (MIC) against Clostridium spp. (MIC0.02 mg/mL). When tested in combination with Cymbopogon martinii, MIC values of 0.01 – 0.02 mg/mL were observed. A topical hydrogel formulation with essential oil entrapped micelles was validated and noteworthy inhibition was observed. The second study focused on the use of essential oils for acne, whereby the essential oil Chrysopogon zizanioides displayed noteworthy antimicrobial activity against dermatological pathogens. Emulsified lotions were developed and these completely inhibited the growth of Cutibacterium acnes and demonstrated cidal activity against the other pathogens. The last study focused on the application of essential oils for the prevention of catheter-associated urinary tract infections. The inhibitory and antibiofilm studies revealed several essential oils having noteworthy activity. Cinnamomum zeylanicum exhibited the most pronounced antimicrobial activity and was incorporated into a crosslinked film containing. The antimicrobial validation of the formulation inhibited growth of a selection of pathogens. These studies demonstrate the successful starting point of determining antimicrobial activity, followed by the most suitable formulation design and thereafter validation of an essential oil containing formulation.

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Artikel online veröffentlicht:
12. Dezember 2022