Planta Med 2022; 88(15): 1512
DOI: 10.1055/s-0042-1759188
Poster Session II

Evaluation of Sideritis species as agents for food supplements

A Argyropoulou∗
1   Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli, Zografou, 15771, Athens, Greece
2   PharmaGnose S. A., 57th km Athens-Lamia National Road, Oinofyta, 32011, Greece
,
M Vanioti
2   PharmaGnose S. A., 57th km Athens-Lamia National Road, Oinofyta, 32011, Greece
,
A L Skaltsounis
1   Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli, Zografou, 15771, Athens, Greece
,
N Adamopoulos
3   Galenica S. A., Kifisia, 14564, Greece
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According to the World Health Organization, 80% of the general population in developed countries use supplements to support specific physiological functions. Natural products are a rich source of molecules that can be effectively used in dietary supplements, as a means of promoting health, relieve and prevent [1], [2]. The current study aims to investigate the chemical content of three Sideritis water extracts, specifically S. scardica, S. perfoliata and S. raeseri and evaluate their potential to be used in food supplements. The samples were treated according to predefined conditions. The plant materials were dried, pulverized and water extracts were prepared. HPLC-DAD, HPTLC, and LC-HRMS were used for analysis and chemical markers were identified. The extracts showed many similarities concerning their chemical profile and most differences were quantitative. Phenolic acids, like 5-caffeoylquinic acid and p-coumaric acid 4-O-glucoside and phenylethanoid glycosides, like forsythoside B and verbascoside were detected. The major metabolites of the extracts were acetylated flavonoids glycosides, such as isoscutellarein 7-O-[6′′′-O-acetyl]-allosyl(1 → 2)glucoside, 4′-O-methylhypolaetin 7-O-[6′′′-O-acetyl]-allosyl(1 → 2)glucoside and isoscutellarein 7-O-[6′′′-O-acetyl]-allosyl(1 → 2)-[6′′-O-acetyl]-glucoside. The extracts were fractionated and purified with preparative column chromatography and prep-HPLC and the structures of the isolated compounds were identified with NMR. The extracts were evaluated for their antioxidant activity, showing IC50 values in the DPPH assay less than 50 µg/ml. In conclusion, Sideritis species provide water extracts rich in bioactive constituents that can be used in the production of food supplements.

The authors declare no conflict of interest.

This research has been financed by ESPA 2014 – 2022 project code: ΣΤΕΡ1 – 0 019 461.



Publication History

Article published online:
12 December 2022

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