Green extraction of bioactive compounds from the traditional Balkan flora using cyclodextrins

In the Balkan area, several plant species have been used in folk medicine over many centuries. In the present study, four plant species that are known from some historical texts as well as modern-day investigations and data bases were examined for their therapeutic action in various skin diseases and conditions. Fumaria officinalis L. is used for eczema, scabies, Satureja montana L. for skin infections, for the treatment of insect bites, bee and wasp stings, Verbascum thapsus L. for wound healing, eczema, acne, and Veronica officinalis L. for the treatment of wounds, or snake bites.

The purpose of this work is to study the extracts of the four species that were produced using two different types of green extraction – with and without beta-hydroxypropyl cyclodextrins. For both the hydro-glycerol extracts produced with rapid extractors type TIMATIC (Technolab) and the extracts that were encapsulated with cyclodextrins, antioxidant activity and total phenolic content were assessed. Furthermore, the physicochemical and the microbiological stability of these extracts were also evaluated. Given their traditional uses as wound healing and anti-inflammatory agents, the extracts were also studied for their effects on cellular proliferation and the transcriptional regulation of genes implicated in relevant regulatory pathways.

Acknowledgments

This abstract is supported by the project EthnoHERBS-H2020-MSCA-RISE-2018 under grant agreement No. 823 973. The authors also acknowledge the support of the Ministry of Education, Science and Technological Development of Republic of Serbia, contract number 451 – 03 – 9/2021 – 14/200 003.

 

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Publication History

Article published online:
12 December 2022