Planta Med
DOI: 10.1055/s-0043-117838
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Effects of Cannabidiol on Morphine Conditioned Place Preference in Mice

James Roland Markos1, Hannah M. Harris1, Waseem Gul2, 4, Mahmoud A. ElSohly2, 3, 4, Kenneth J. Sufka1, 2
  • 1Department of Psychology, University of Mississippi, University, MS, USA
  • 2Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS, USA
  • 3Department of BioMolecular Science, University of Mississippi, University, MS, USA
  • 4ElSohly Laboratories Inc., Oxford, MS, USA
Further Information

Publication History

received 19 April 2017
revised 11 July 2017

accepted 25 July 2017

Publication Date:
09 August 2017 (eFirst)


This study sought to determine whether the cannabis constituent cannabidiol attenuates the development of morphine reward in the conditioned place preference paradigm. Separate groups of mice received either saline or morphine in combination with one of four doses of cannabidiol using three sets of drug/no-drug conditioning trials. After drug-place conditioning, morphine mice displayed robust place preference that was attenuated by 10 mg/kg cannabidiol. Further, when administered alone, this dose of cannabidiol was void of rewarding and aversive properties. The finding that cannabidiol blocks opioid reward suggests that this compound may be useful in addiction treatment settings.