One-Pot Sequential Synthesis of Pyrido[2,3-d]pyrimidine-Fused Isoxazoles: Regio-and Chemoselectivity in Green Solvent

Abdolali Alizadeh; Seyed Ali Hosseini

doi:10.1055/s-0043-1775493

Synthesis, Table of Contents

Synthesis 2025; 57(16): 2496-2504
DOI: 10.1055/s-0043-1775493

paper

One-Pot Sequential Synthesis of Pyrido[2,3-d]pyrimidine-Fused Isoxazoles: Regio-and Chemoselectivity in Green Solvent

Authors

Abdolali Alizadeh∗
Seyed Ali Hosseini

Abstract

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Abstract

A new method has been reported for synthesizing derivatives of isoxazolo[4′,5′:5,6]pyrido[2,3-d]pyrimidine through the reaction of arylglyoxal, 1,3-dimethylbarbituric acid, and 5-aminoisoxazole in water as a green solvent. It involves a one-pot sequential multicomponent reaction, which was carried out in two different approaches (with and without purification of 5-aminoisoxazole). The method forms five chemical bonds and offers advantages such as easy product purification, availability of raw materials, high reaction efficiency, and environmental friendliness. This synthetic strategy has the potential to advance developments in heterocyclic chemistry.

Key words

arylglyoxal - 1,3-dimethylbarbituric acid - regioselective - chemoselective - hydroxylamine hydrochloride - four-component reaction - environmental sustainability

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References

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