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Synthesis 1986; 1986(2): 117-120
DOI: 10.1055/s-1986-31490
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New Convergent Synthesis of Germacranolides with a trans-Fused γ-Lactone

Gordon L. Lange* , Moses Lee
  • *Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
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Publikationsdatum:
20. August 2002 (online)

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A new concerted approach to the formation of the trans-fused γ-lactone which bridges C-6 and C-7 in the germacranolide family of sesquiterpenoids is reported. Starting with enone 3 and using this approach, the synthesis of 2, a geometric isomer of the naturally occurring germacranolide 1, is outlined.