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Synthesis 1986; 1986(5): 400-402
DOI: 10.1055/s-1986-31651
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A Facile Synthesis of Polyfunctionally Substituted Pyridines from Ethoxycarbonylmalonaldehyde

Sigeru Torii* , Tsutomu Inokuchi, Minoru Kubota
  • *Department of Industrial Chemistry, School of Engineering, Okayama University, Okayama 700, Japan
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Publication Date:
27 September 2002 (online)

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A facile access to 2,3-disubstituted-5-ethoxycarbonylpyridines (50-66% yields), derivatives of biologically and medicinally important nicotinic acid, is explored. The method involves the reaction of ethoxycarbonylmalonaldehyde with tosyl chloride and then with β-amino-α,β-unsaturated esters, ketones, or nitriles in the presence of pyridine.

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