One-Pot Synthesis of S-Acetamidomethyl-N-fluorenylmethoxy-carbonyl-L-cysteine (Fmoc-Cys(Acm)-OH)

F. Albericio; A. Grandas; A. Porta; E. Pedroso; E. Giralt

doi:10.1055/s-1987-27912

Synthesis 1987; 1987(3): 271-272
DOI: 10.1055/s-1987-27912

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One-Pot Synthesis of S-Acetamidomethyl-N-fluorenylmethoxy-carbonyl-L-cysteine (Fmoc-Cys(Acm)-OH)

F. Albericio^* , A. Grandas, A. Porta, E. Pedroso, E. Giralt

^*Departament de Química Orgànica, Facultat de Química, Universitat de Barcelona, E-08028 Barcelona, Spain

Abstract

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A new strategy for the preparation of S-acetamidomethyl-N-fluorenyl-methoxycarbonyl-L-cysteine is reported. Inexpensive, readily available reagents are used, and no special equipment is required. A very homogeneous product is obtained after a simple crystallization at the end of the process, without purification of intermediates.

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