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Synthesis 1987; 1987(4): 391-393
DOI: 10.1055/s-1987-27957
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A Comparative Investigation of the Reactions of α-Metallomethyl Isocyanides with α,β-Unsaturated Ketones

Mark Westling* , Tom Livinghouse
  • *Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, U.S.A.
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Publication Date:
20 August 2002 (online)

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The nucleophilic addition of lithiomethyl isocyanide to representative α,β-unsaturated ketones has been examined. The ratio of 1,2- to 1,4-addition is dependent upon the inclusion of ligating cosolvents. In addition, the reactions of alternative α-metallomethyl isocyanides with α,β-unsaturated ketones have been studied.