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Synthesis 1987; 1987(4): 404-406
DOI: 10.1055/s-1987-27964
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Preparation of Acetals of α-Epoxyketones and Their Chemoselective Hydrolysis Into α-Epoxyketones by Acidic Moist Silica Gel

Pascal Lescure* , François Huet
  • *Laboratoire des Carbocycles, U.A. CNRS 478, Bâtiment 420, Université de Paris-Sud, F-91405 Orsay Cedex, France
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Publication Date:
20 August 2002 (online)

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Sulfur ylides react with monoacetals of α-dicarbonyl compounds to give the expected epoxyacetals in satisfactory to high yields. These lead to α-epoxyketones by chemoselective hydrolysis by acidic moist silica gel.

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