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Synthesis 1987; 1987(5): 514-515
DOI: 10.1055/s-1987-27989
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One-Step Synthesis of 2- and 4-Nitrobenzyl Cyanides

Asher Kalir* , Rivka Mualem
  • *Institute for Occupational Health, Sackler Faculty of Medicine, Tel Aviv University, Israel 69978, and Israel Institute for Biological Research, Ness Ziona, Israel
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Publication Date:
18 September 2002 (online)

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2-Nitrobenzyl cyanide (2) and analogs were obtained in fair to good yields by reacting the corresponding bromides with sodium cyanide and hydrogen cyanide in dimethyl sulfoxide. Hydrogen cyanide could be generated in situ from an excess of sodium cyanide and trifluoroacetic acid.