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Synthesis 1987; 1987(9): 816-817
DOI: 10.1055/s-1987-28084
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A Single-Step Synthesis of Tamoxifen Using Palladium-Catalyzed Cross-Coupling

Mohammed I. AI-Hassan*
  • *Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh-11451, Saudi Arabia
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Publication Date:
12 September 2002 (online)

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The synthesis of tamoxifen, a biologically active tetrasubstituted olefin was achieved via palladium-catalyzed cross-coupling of vinylmetal with 2-(4-bromophenoxy)-1-dimethylaminoethane.

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